Department of Virology

  Teaching Staff:

Head of the department:	Professor Iryna V. Dzyblik, Doctor of Medical Science
Teaching Staff Members:	Assistant Professors: Svetlana G. Voronenco, Galina G.Kovalischin, Valentyn G. Porohnyckiy, Alla P. Mironenko Assistant: Olena V. Kovalyuk
The central scientific research team:	Olena P. Trochimenco, Candidate of Biological Science, senior research officer; Valentina M. Plugatir, research officer

History Data:

The Chair of Virology was founded as a part of Kiev Institute for the Advancement of Physicians (KIAP) on the 10^th of March of 1985 according to Order # 822 of the 2^nd of August of 1984 by the Soviet Union Ministry of Health. Founder and the first head of Chair was Girin Vitaliy Mikolayovich, doctor of medical science, professor and member of the Science Academy of the Higher School of Ukraine, the honored science and technology worker, President of KIAP, that was lately renamed the Kiyv Medical Academy of Post-Graduate Education.

Professor Girin V. M. was an alumnus of the Kyiv scientific school of microbiologists and virologists, one of the founders of the new important field of science in Ukraine – sanitary microbiology and virology. Professor Dzyblik I. V. has been heading the Chair since April 2002. Her scientific and pedagogical experience amounts to 26 years. She is a Physician of Highest Rank. Dzyblik I. V. is an expert in rotavirus and VIH infections, chemotherapy and prevention of virus diseases, interferon and its inductor issues. She is the author of more than 230 publications including 11 patents and certificates of authorship, is a coauthor of four manuals and textbooks in virology. Dzuyblik I. V. is a member of the Ministry of Health and the Academy of Medical Science of Ukraine Commission for Control and Rational Use of Antibiotics and Antiviral Drugs in Ukraine.

Teaching and Methodological Work:

The educational and methodical work is carried out On two educational clinical bases (Kiev Clinical hospital #5 and at the Institute of cellular therapy) Chair’s premises, totaling 400 square meters of space, including a certificated room for working with viruses of the third and fourth categories of pathogenity (certification granted on 22 July 2002), state-of-the-art medical equipment, and a vivarium.  The modern technical resources (INTERNET, computing, multimedia, photocopying equipment, projection and video facilities) are broadly used in the educational process.

The following lecture series are carried out by the Chair according to budget and commercial programs and plans that approved by the Ministry of Health of Ukraine and by individual plans of participants:

Specialization: on virology under the individual plan (3 months)

Pre-certification: on virology (1 month)

Topical Advanced Training: “Laboratory diagnostics of VIH infections, viral hepatitis B, C, D, herpesviral infections, and syphilis”. For physicians-virologist, physicians-laboratory assistants, Sanitary and epidemiological stations, Station of blood transfusion, centers of the VIH infections/AIDS, diagnostic laboratory and centers, anti-plague stations (AS), bacteriologists and epidemiologists, Sanitary and epidemiological stations and AS, physicians-infectionists, physicians-dermatovenerologists (1 month); modern problems of TORCH-infections for physicians-virologist, physicians-laboratory assistants, Sanitary and epidemiological stations, Station of blood transfusion, centers of the VIH infections/AIDS, diagnostic laboratory and centers, anti-plague stations (AS), bacteriologists and epidemiologists, Sanitary and epidemiological stations and AS, physicians-infectionists, physicians-dermatovenerologists (2 weeks); pressing questions of modern medical virology for physicians-virologist, physicians-laboratory assistants, Sanitary and epidemiological stations, Station of blood transfusion, centers of the VIH infections/AIDS, diagnostic laboratory and centers, anti-plague stations (AS), bacteriologists and epidemiologists, Sanitary and epidemiological stations and AS, physicians-infectionists, physicians-dermatovenerologists (2 weeks)

Training: on virology under the individual plan (1 month)

Internship: The training courses in virology and microbiology for graduates of medical schools (4 months)

Training courses for physicians and intermediate medical staff of Ukraine are also carried out by the Chair through visiting lectures and seminars cycles in the regional and district medical and prevention organizations.

To confront spread of HIV/AIDS and viral hepatitis, the Etiology, Clinics, Pathogenesis, Laboratory Diagnostics and Prophylactics Doctor Training Center was established in 1992 using the Chair’s facilities. New programs, methodical recommendations, cycles on current AIDS and viral hepatitis prevention issues have been developed and implemented

Self-sustained activity:

Specialization in virology for physicians and biologists. Three month duration.

Probation in virology for foreigners by individual plans. One month duration.

Scientific Research Activities:

Projects and research work:

• Developing the scientific basis for effective laboratory diagnostics methods of hepatitis A, rotaviral and some of the enteroviral infections.

• Study of pathogenic mechanisms of the rotaviral infections and improvement of methods of there laboratory diagnostics.

• An experimental basis of the methylsilicon acid based hydrogel applications for laboratory diagnostics and treatment of rotaviral infections.

• Identification of viral infections impact on pathology in post- and neonatal periods.

• Development of the theoretical basis in application of natural dispersible mineral sorbents for purification and disinfection of water and human organism detoxication in environmental disaster areas.

• Saponite – based sorption compounds for human organism detoxication in acute viral and bacterial intestinal infections.

• Development of methods for prevention, diagnosis and treatment of hemoblastosis and solid tumors with application of platinum compounds.

• Scientific and methodological substantiation of effectiveness of training of the specialists for treatment and prevention institutions on HIV infection problems

• Rotaviral infection: the presently observed features of etiology, pathogenesis, immunogenesis and epidemiology in children; development of experimental and theoretical basis for creating new preventive and therapeutic compounds, determination of the principles of their practical use.

The main scientific advances of the Chair:

• A state-of-the-art methods for isolation, purification and concentration of rota- and enteroviruses from clinical material of patients and environmental objects with application of bentonite, aminoetoxiaerosil-2 and enterosgel was proposed.

• A new model of rotoviral infection for studying the pathogenesis, effectiveness of medical treatment and specific prevention studies using the gnotobiotic piglets was suggested and developed.

• For the first time a new highly immunogenous vaccine for prevention of rotoviral gastroenteritis was created. Prepared and approved normative-technical documentation for “The new vaccine with increased immunogenity for prevention in rotaviral gastroenteritis” for veterinary use. The vaccine has passed the State tests and was recommended for industrial production.

• A new biotechnology of virus cultivation in synchronic cell systems with application of macromolecular platinum complex was developed.

• A new compound was offered, that binds pathogenous chemicals, bacteria and heavy metals, extracts them from the organism, as well as replenishes organism with micro- and macro-elements.

• The new biotechnology for cultivate cellular cultures of the humans and animals in a fixed-bed system from tapes of polythene.

• Was developed the technique of medical product "Laferon"application in complex therapy rotavirus infection at newborns.

• Was developed a new technique of complex inspection of newborns from risk groups on presence infections by viruses of a hepatites B and C.

Publishing activities. Publications of Chair’s employees:

1. “Manual for practical training in laboratory diagnosis of viral infections”. – “Vyshcha Shkola”., 1992. – 303 P.: Figs. – Rus. ISBN 5-11-003841

2. “Textbook in medical virology”. – K.: Zdorov’e., 1995. – 368 P.: Fig.. ISBN 5-311-00855-5.

3. “Educational textbook of laboratory diagnosis of HIV infections/AIDS issues”. - – K.: Medprominfo., 1999. – 160 P.:Fig. ISBN 966-573-160-2.

4. Textbook “Viral Hepatitis B in New-Born Children”. K., 2001. – P. Fig.

5. Handbook “Epidemiology”. – K.: Zdorov’a, 1993. – 464 P.ISBN 5-311-00742-7.

6. Handbook “Epidemiology”. – K.: Zdorov’a, 1998. – 480 P.ISBN 5-311-01136-x.

7. Handbook “Epidemiology and the Principles of Medical Parasitology”. – K.: Zdorov’a, 2001. – 632 P.ISBN 5-311-01185-8.

8. The virus hepatites in at newborn children. The Educational -methodical manual »-Kiev.-2001.-90 p.

9. Rotavirus infection. The Educational -methodical manual -Kiev.-Olprint.-2004.-116 с. ISBN 966-8326-46-6.

10. The manual on chemotherapy of virus infections Kiev.-Olprint.-2004.-176 с. ISBN 966-8326-46-8.

11. Parenteral virus hepatites. The Educational -methodical manual.-Kiev, Olprint.-2005.-168 p. ISBN 966-391-062-3.

Monographs “Acquired Immunodeficiency Syndrome”, “Viral Hepatitis”, “What Do We Know about AIDS?”, numerous methodical recommendations, methodical instructions and informational letters related to medical and sanitary virology; methodology for physicians preparing for diverse specialties on issues of HIV infections/AIDS were prepared and published by the Chair.

Clinical work:

Consulting support in issues of viral infections is constantly provided to institutions of practical medicine by collaborators of the Chair who work as consultants and experts of Ministry of Health of Ukraine.

The Chair’s laboratory is authorized by the City Regime Commission to work with viruses of the third and fourth pathogenity categories (certification granted on July 22, 2002). Material and technical facilities of the laboratory of the Chair of Virology, presence of the collection (museum) of both pure and clinically obtained stamps of pathogenous viruses, as well as qualification of the personnel, allow performing all kinds of tests on laboratory animals, cell cultures and chicken embryos. In early 2003, the Chair of Virology was accredited by the Pharmacological Committee of the Ministry of Health of Ukraine to conduct specific pharmacological tests of antiviral, virucidal, disinfecting drugs, as well as to perform virological scientific research, related to clinical tests of the medicine.

The Ministry of Health of Ukraine Hygienic Regulations Committee has accredited the laboratory of the Chair of Virology to perform research on hygienic specification of potentially dangerous factors of biological (viral) origin (accreditation granted on June 17, 1999).

The State Sanitary and Epidemiological Service of Ukraine of the Ministry of Health of Ukraine has issued a certificate of attestation, granting the laboratory of the Chair of Virology the right to perform medical, biological, sanitary-virological and other virological research, related to safety of products for human health. (Certificate of Attestation issued on June 17, 1999).

The base laboratory of the Chair of Virology is authorized to:

Perform medical and biological tests of food raw materials and foodstuffs for virological parameters, and to make conclusions as to biological impact of those parameters and possibility of using the food for human consumption;

Perform sanitary and virological tests of food raw materials, foodstuffs, potable water, non-alcoholic and low-alcohol beverages, mineral waters, environmental objects, household items, equipment and individual devices for additional purification of potable water, etc.;

Assess the virucidal and decontamination activity of disinfectants, surface-active compounds, shampoos and soap with bactericidal and virucidal properties, other detergents.

After tests have been conducted, the medical test program is issued, along with the protocols of medical tests results and other official documents, as required.

The Chair’s employees conduct the expert assessment for certification and registration of means of individual protection, condoms (determining the barrier properties relative to agent, causing HIV/AIDS, viral hepatitis, and other sexually transmitted diseases), glassware for virological research and cell culture cultivation, equipment for modern diagnostic research using immune-ferment analysis techniques, devices for purification of potable water from viruses, in Ukraine.

After tests have been conducted, the medical test program is issued, along with the protocols of medical tests results and other official documents, as required.

Address:

04112, Kiev-112, Dorogozhytska str., 9
Tel.: (044) 205-49-88; 456-28-89